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备孕过久不怀孕,先去查查激素吧

发布日期:2024-08-27 19:11:52编辑:秩名


有数据显示:已婚育龄夫妇中,有8%~15%受到不孕症的困扰。其中一个很重要的原因就是缺乏孕激素,这类患者占不孕症患者的34%~35%,在反复流产的患者中有29%~60%是由于缺乏孕激素造成的。
 
电视剧《夫妻那些事》中陈数饰演的女建筑设计师林君和黄磊饰演的丈夫为了备孕,非常在意饮食和运动,没想到却被诊断为因雄性激素过高导致不孕。女主角哭笑不得:“我这么努力的调养,怎么倒调养出雄性激素来了?”
 
雄性激素是维持男性性征的主要激素,但女性的卵巢与肾上腺都有产生少量雄激素的功能。女性体内雄激素的功能包括:为雌激素提供合成底物,刺激腋毛等的生长,促进蛋白质合成及骨髓造血,与性欲有关。正常情况下,一个成年女性体内每日的雄激素分泌量仅占1%,约为男性的1/20,血液中的含量约为男性的1/10,如果超出这个数值,就可判定为雄性激素过高,医学上称为“高雄激素血症”,而这可引发不孕,但很多女性经过治疗,都能够顺利怀孕。
 
所以,我建议备孕时间过长的夫妻,应首先去医院检查下生殖激素六项。生殖激素六项检查是生殖科常规基础检查,也叫性激素六项,主要包括促卵泡生成激素、促黄体生成素、催乳素、雌二醇、黄体酮、睾酮等。但目前国内尚无完整的、统一的内分泌性激素测定值,且由于各种试剂的来源,测定的方法,数据的计算,采用的单位不同,即使同一激素标本,各实验室所得结果也不完全相同。
 
女性检查内分泌最好在月经来潮后的第3~5天,早9点空腹抽血检查,效果最为精准。这一段时间属于卵泡早期,可以反映卵巢的功能状态。但对于月经长期不来潮或不孕不育而且又急于了解检查结果者,则随时可以检查,这个时间就默认为月经前的时间,其结果也就参照黄体期的检查结果。男性只要没有剧烈运动,生活规律,上午8:00—11:00点空腹可进行检查。
 

促卵泡生成素(FSH)

 
促卵泡生成激素是垂体前叶嗜碱性细胞分泌的一种糖蛋白激素,对于女性而言,其主要功能是促进卵巢的卵泡发育和成熟。血FSH的浓度在排卵前期为1.5~10mIU/ml,排卵期为8~20mIU/ml,排卵后期为2~10mIU/ml。一般以5~40mIU/ml作为正常值。FSH值低见于雌孕激素治疗期间、席汉氏综合征等。FSH高见于卵巢早衰、卵巢不敏感综合征、原发性闭经等。FSH高于40mIU/ml,则对氯米芬之类的促排卵药无效。
 
对于男性而言,输精管生长以及保持精子产生往往受FSH的调节,正常值为1.42~15.2U/L,过高过低则均属于不正常。无精症和少精症男性的FSH水平通常是升高的,FSH升高同时还见于原发性睾丸衰竭和精细管发育不全(即klinefelter综合征)、饥饿、肾衰竭、甲亢和肝硬化等;而睾丸肿瘤一般FSH浓度降低。FSH可刺激支持细胞分泌雄激素结合蛋白,提高曲细精管局部雄激素浓度。
 

促黄体生成素(LH) 

 
促黄体生成素垂体前叶嗜碱性细胞分泌的一种糖蛋白激素,对于女性其主要功能为促使排卵,在FSH的协同作用下,形成黄体并分泌孕激素。血LH的浓度,在排卵前期为2~15mIU/ml,排卵期为30~100mIU/ml,排卵后期为4~10mIU/ml。一般在非排卵期的正常值是5~25mIU/ml。低于5mIU/ml提示促性腺激素功能不足,见于席汉氏综合征,高FSH如再加高LH,则卵巢功能衰竭已十分肯定,不必再做其他检查。LH/FSH≥3则是诊断多囊卵巢综合征的依据之一。此外,LH还用于确定绝经期、排卵时间以及监控内分泌治疗。
 
而对于男性来说,LH可促进间隙细胞发育及分泌睾酮,从而促进生精上皮的发育和精子生成。LH浓度升高,见于性腺功能减退,原发性睾丸衰竭和精细管发育不全,肾功能衰竭,肝硬化,甲亢及严重饥饿。垂体前叶激素分泌不足可引起LH水平降低,男女低LH水平均可导致不育症,低LH值可提示垂体或下丘脑的某些功能障碍。在鉴别诊断下丘脑,垂体或性腺功能障碍时,LH浓度测定是常规项目并且与FSH一同测定。
 

催乳素(PRL)

 
催乳素是由脑垂体前叶的嗜酸性细胞分泌的,是一种单纯的蛋白质激素,催乳素的分泌受下丘脑分泌的两种激素所调节,一是催乳素抑制素,可以抑制催乳素的过度分泌,二是催乳素释放激素,可刺激垂体嗜酸性细胞分泌催乳素。对于女性而言,其主要功能是促进乳腺的增生、乳汁的生成和排乳。在非哺乳期,血PRL正常值为0.08~0.92nmol/L。高于1.0nmol/L即为高催乳素血症,过多的催乳素可抑制FSH及LH的分泌,抑制卵巢功能,抑制排卵。PRL浓度的测定,有助于下丘脑一垂体功能障碍的诊断,垂体肿瘤会造成高催乳素血症,高PRL水平一般与溢乳及闭经相关,经过药物治疗PRL下降后月经可恢复正常。
 
对于男性而言,在正常生理状态下,催乳素抑制素控制着催乳素的分泌,男子血液中催乳素的正常浓度为0~0.84nmol/L。连续3次测定催乳素高于0.84nmol/L,即可诊断为高催乳素血症,应进一步做蝶鞍CT或磁共振成像检查,以排除是否有垂体腺瘤。高催乳素血症时,下丘脑-垂体-睾丸轴功能降低,雄激素水平低,引起少精子症或无精子症,有的有性功能障碍,出现阳痿,因而会引起不育,发病率约为4%。
 

雌二醇(E2)

 
对于女性而言,雌二醇由卵巢的卵泡分泌,主要功能是促使子宫内膜转变为增殖期和促进女性第二性征的发育。血E2的浓度在排卵前期为48~521pmol/L,排卵期为70~1835pmol/L,排卵后期为272~793pmol/L,低值见于卵巢功能低下、卵巢功能早衰、席汉氏综合征。血清E2测定对评价各种月经异常是非常有用的指标,如女孩青春期提前或延迟,原发性或继发性闭经、卵巢早衰等。
 
对于男性而言,E2参与垂体促性腺激素释放的调节,可抑制男子垂体LH和FSH,而使间质细胞分泌T量减少,血清E2降低,可使血清LH、FSH和T浓度升高。在男性,若有女性化综合征,乳房女性化以及睾丸癌等也会有E2上升。
 
雌二醇值增高的病理病因包括:卵巢疾患,如卵巢颗粒层细胞瘤、卵巢胚瘤、卵巢脂肪样细胞瘤、性激素生成瘤等,均表现卵巢功能亢进,雌二醇分泌量增加;心脏病及其他疾病,如心肌梗死、心绞痛、冠状动脉狭窄、系统性红斑狼疮、肝硬化、男性肥胖症亦会引起雌二醇分泌量增加。
 
雌二醇降低的病理原因包括:卵巢疾病,如卵巢缺如或发育低下,原发性卵巢衰竭、卵巢囊肿;垂体性闭经或不孕,或甲低/甲亢、柯兴氏综合征、阿狄森氏病、恶性肿瘤、较大范围的感染、肾功能不全、脑及垂体的局灶性病变等,均可使血浆雌二醇降低。
 

黄体酮(P) 

 
对于女性而言,黄体酮由卵巢的黄体分泌,主要功能是促使子宫内膜从增殖期转变为分泌期,其浓度用于判断有无排卵及未孕女性的黄体功能。血P浓度在排卵前为0~4.8nmol/L,排卵后期为7.6~97.6nmol/L,排卵后期血P低值,见于黄体功能不全、排卵型功能失调性子宫出血等。
 
对于男性而言,成人的正常值为0.10~0.84ng/ml。但对于男性不育门诊来说,黄体酮增高的参考意义并不大,若不明原因P值增高,则建议去专业医院进一步排查。 
 

睾酮(T) 

 
女性体内睾酮,50%由雄烯二酮转化而来,肾上腺皮质分泌的约25%,仅25%来自卵巢,主要功能是促进阴蒂、阴唇和阴阜的发育。其对雌激素有拮抗作用,对全身代谢有一定影响。女性血T正常浓度为0.7~3.1nmol/L。血T值高,叫高睾酮血症,可引起不孕。患多囊卵巢综合征时,血T值也增高。根据临床表现,必要时再测定其他激素。
 
对于男性来说,T与精子数量和活动度密切相关,少精症和无精症者血清和精液T量低于常人,只有与靶细胞结合的游离T才能促进细胞分裂和成熟。
 
睾酮浓度增高常见于睾丸良性间质细胞瘤、先天性肾上腺皮质增生症、真性性早熟、男性假两性畸形、女性男性化肿瘤、多囊卵巢综合征、皮质醇增多症和应用促性腺激素、肥胖以及晚期孕妇,血中睾酮浓度皆可增高。
 
睾酮浓度降低常见于男子性功能低下、原发性睾丸发育不全性幼稚、高催乳素血症、垂体功能减退、系统性红斑狼疮、骨质疏松、隐睾炎、男子乳房发育等。
 
有很多人一听生殖激素六项检查,普遍认为是女性的事情,事实上,维持男性生育力,也同样必须有合适的激素环境。与男性生殖功能有关的激素主要有下丘脑分泌的促性腺激素释放激素(GnRH)、垂体前叶分泌的促卵泡成熟激素(FSH)、黄体生成素(LH)、催乳素(PRL)以及睾丸自身分泌睾酮(T)和双氢睾酮(DHT),这些激素都可通过下丘脑-开体-睾丸轴作用于睾丸的支持细胞,产生精子以保证男性的生育力,作用于间质细胞以维持男性性征和性功能。其中任一激素含量异常,都可间接或直接引起睾丸生精功能障碍,从而影响男性生育力。据报道,不育男子中10%存在内分泌功能异常。在发达国家,内分泌检查已成为检测男子不育的主要手段。
 
因此,对于怀孕困难的夫妻,不仅需要准妈妈做激素检查,准爸爸也同样需要做这六项检查,了解性激素与男性生殖功能的关系,对于深讨某些男性不育的病因、发病机理和诊治以及计划生育将不无裨益。
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